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Did COVID-19 Evolve Naturally?



The severe acute respiratory syndrome coronavirus 2 is the virus responsible for the 2019 novel coronavirus disease or COVID-19. SARS-CoV-2 is a member of a larger family of coronaviruses that can cause illnesses that range widely in severity. A second outbreak of severe illness would also occur in 2012 in Saudi Arabia with the Middle East Respiratory Syndrome or MERS.

SARS-CoV-2 is a particularly dangerous strain of coronavirus because of its perfect balance of contagiousness , incubation period, and fatality rate.

OUTBREAK

On December 10th, 2019, Wei Guixian of Wuhan, China, began to feel ill, becoming one of the earliest known cases of a SARS-CoV-2 infection. In the coming days, both Ai Fen, a top director at Wuhan Central Hospital and Li Wenliang , a Wuhan doctor, had posted information on the Chinese messaging platform WeChat about the new virus. By December 31st, Wuhan health officials had confirmed 27 cases of the new illness and subsequently closed the market they thought was related to the virus’ outbreak. Officials at the Hubei Provincial Health Commission ordered labs, which had already determined that the novel virus was similar to SARS, to stop testing samples and to destroy existing samples.

The reality of the contagious nature of SARS-CoV-2 would soon become dangerously apparent.

STRUCTURE

Structurally, SARS-CoV-2 is composed of a spherical shell made up of a lipid membrane encompassing a core that contains the virus’ genetic material. While spike proteins are a characteristic of all coronaviruses, the genomic data has revealed a peculiarity of SARS-CoV-2, it binds and fuses to the host’s cell wall as a result of a cleavage site that’s activated by the enzyme furin. The significance of this finding is that furin is not only present on lung cells, but also in the tissues of the liver and small intestine, allowing SARS-CoV-2 to have multiple potential infection points in the human body.

EVOLUTION

The nature of how SARS-CoV-2’s spike proteins behave also offers a glimpse of its origin. Researchers have found that the receptor-binding domain portion of the SARS-CoV-2 spike protein had evolved to effectively target proteins expressed by the ACE2 gene. SARS-CoV-2 spike proteins are so effective at binding to human cells, that scientists have concluded that this feature was the result of natural selection and not the product of genetic engineering. This evidence for natural evolution has been supported by data on SARS-CoV-2’s overall molecular structure or its backbone.

From the genomic sequencing analysis, researchers have concluded one of two likely possible scenarios for SARS-CoV-2. The 2003 SARS outbreak was attributed to direct human exposure to civets while the 2012 MERS outbreak was a result of exposure to camels. In this theory, the originating animal of SARS-CoV-2 is proposed to be bats since it’s structure is very similar to bat coronavirus. Because the distinct features of SARS-CoV-2’s spike protein would have already evolved prior to entering humans, in this theory the current pandemic would have emerged rapidly from either a small infected group or even a single infected individual.

The SARS-CoV-2 cleavage site appears to be similar to that of strains of bird flu that have been shown to transmit easily between people.

As of April 2020, the SARS-CoV-2 spike protein is being heavily used as a target antigen in vaccine development. It’s hopeful that SARS-CoV-2 strength, it’s spike protein, will also serve as it’s weakness, becoming the unique molecular identifier that our immune systems will “remember” to resist COVID-19 infection.

REFERENCES
Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine
https://www.nature.com/articles/s41423-020-0400-4

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
https://www.ncbi.nlm.nih.gov/pubmed/32057769

The proximal origin of SARS-CoV-2
https://www.nature.com/articles/s41591-020-0820-9?fbclid=IwAR3QtKR9Z6C5wyVclIetOkzHggkgS_H10Sk-_y8CDoTINs10NXQo4QQEU1Q

Mutational Analysis of the Murine Coronavirus Spike Protein: Effect on Cell-to-Cell Fusion
https://www.sciencedirect.com/science/article/pii/S0042682285700566

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28 comentários

  1. Good old fashioned Chinese market zoonotic virus theories . Yay! Nothing about Bill Gates or 5g or exosomes or Trump. No conspiracies, That was 3 weeks from today. The good old days…

    Before The Stupidity Pandemic took hold.

  2. CHina identified virus 27.12.19 and inform WHO 3.1.20 which is 4 working days over a holiday period. China inform USA on 3.1.20 and Trump only ban China travel 31.1.20 which was 4 weeks later. So who is more incompetent? Only racists will say Chinese

  3. It would be highly unusual for a novel coronavirus originating in bats to suddenly emerge exhibiting both high binding affinity for the human ACE2 receptor and the ability to cause high human to human infectivity simultaneously. There would normally be evidence of several previous mini-epidemics of early forms of the virus as it gradually acquired these properties via further mutations in the new zoonotic hosts including humans.
    If this evidence is not found then a lab origin becomes probable.
    If the CCP wanted to prove the virus did not come from the lab they should be allowing independent epidemiological investigation, not blocking it.
    The fact they seem to have stopped looking suggests they already know where it came from.

  4. I dont know anything about The 10 COMMANDMENTS but I know a 1 COMMANDMENT, Stay away from your father and mother and family, 6 FEET APART! GOD is a COWARD, GOD is a liar. Why does everytime I write, search God on a search engine this Garbage name keeps popping out. The Garbage or Junk name is Jesus who didn't care about our health and KEEPS killing all his followers by CORONA. Thats it GOD IS A LIAR AND A COWARD. GOD TROLLS! Beware! Dont be a part of the problem, be a solution. Can you do that GOD who always lies and is a COWARD.
    Why does school teach you about religion by giving your money to them?
    Now school is closed and no one will hear their nonsense religion
    GOD TROLLS! Beware!
    I dont believe in GOD but I do know we empower them by worship! They need us to make them ALIVE! While they take away our FREEDOM OF CHOICE!

  5. It's possibility of coming out of lab is not even raised in this video. This video is fake. They want to mislead people by showing fancy clips of researchers in white coat doing special stuff.
    It coming out of bat + some other animal is only a probability, no one can prove it anyway. And by this time china + WHO would have erased lot of proofs from the lab. Looking at the behaviour of media to hush any contradictory theory, it is clear that it is all planed for a ulterior purpose.
    People nowdays in science lack integrity (unlike the old great scientists).All the reputed magazines are susceptible to corruption too.
    So if you are consciously promoting lies, you will suffer heavily. Leave your high paying job(full of lying/misleading) at least your heart will be right place.

  6. In early time, different types of coronavirus had been found in China (SAR virus) and in Middle East (MERS virus) . Recently, Covid-19 become pandemic in the World. Humans are easily expose to viruses. Scientists had found many different mutants of Covid-19 exist in the World. The infection and mortality rates are getting higher and higher from one to another country. Climate change is the cause of concern for the mutation of virus. The different mutants with different geographical locations provide solid evidence global warming is critical to cause mutation for viruses and bacteria. The World leaders must take immediate action to protect the future of disasters .

  7. Why was sars and mers not ever an issue? No need for mass reaction? Why did completely different mutations with no pressure from vaccines to mutate. Imitate so quickly and appear independently in different countries at the same time? Your not being told something. Maybe theres a highly deadly version and we released a mutated version to choke out and dominate the deadlier version ? It matches yo completely with all the actions of Gov and different information. Honestly theres no telling but something is not being told to us for sure. Why let cancer, heart disease, mental health, and world economies no longer be anywhere near as important as our 7th version of covid so suddenly the flu and every threat to the world is nothing compared to this and we need unknown unprecedented action why? Makes sense us version started in rural america in the middle of the us right in time to match the other strains in different countries. It also makes sense why some information you'll be fine and show no symptoms some crazy reports 40 percent will die. I'm not saying anything as fact just it all doesn't add up and were definitely not being told the truth.

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